Adaptive Treatment for Pregnant Women Who Abuse Drugs

Researchers have developed an intensive relapse-prevention program for pregnant women who abuse drugs. A SMART design is being used to develop an adaptive intervention where the intensity and scope of the relapse-prevention program is adjusted based on the evolving status of each woman.

  • PIs: Hendrée Jones, Margaret Chisolm
  • Location: Johns Hopkins University
  • Funding: NIDA Project R01DA014979

Adaptive Treatment for Growth Suppression in Children with ADHD

Studies show that the use of stimulants for the control of ADHD in youth leads to a reduction in height gain. This study uses a SMART design to examine the effectiveness of temporary breaks in medicinal treatments and caloric supplementation for the treatment of stimulant-induced weight and growth suppression.

  • PI: James G. Waxmonsky
  • Location: Florida International University
  • Funding: NIMH Project R01MH083692

Adaptive Intervention for Adolescent Marijuana Use

Researchers in this study are developing an adaptive treatment for adolescent marijuana users. They are studying the use and combination of several efficacious treatments, including behavioral therapy, contingency management, behavioral parent training, and working memory training via a SMART trial.

  • PI: Alan J. Budney
  • Location: Dartmouth College
  • Funding: NIDA Project R01DA015186

Adaptive Interventions for Children with ADHD

The aim of this SMART is to understand whether to begin with medication or behavioral therapy for children with ADHD, and whether to intensify or augment initial treatment for children who do not respond to treatment.

  • PI: William Pelham
  • Location: Florida International University
  • Funding: U.S. Department of Education-funded, completed project

Adaptive Treatment for Cocaine Dependence

A SMART design is being implemented to develop an adaptive intervention to increase treatment engagement and decrease cocaine use for patients who are cocaine dependent. The study also examines whether patient choice of care affects patient outcomes.

  • PI: James R. McKay
  • Location: University of Pennsylvania
  • Funding: NIDA Project P01AA016821

Adaptive Approach to Naltrexone Treatment for Alcoholism

Naltrexone (NTX) is an opioid receptor antagonist used to prevent alcoholism relapse. This trial examines how to define “non-response” to treatment with NTX and what treatments are most effective for those who do or do not respond to the initial treatment.

  • PI: David Oslin
  • Location: University of Pennsylvania
  • Funding: NIAAA Project R01AA017164

Adaptive Treatment for Adolescent Obesity

Adaptive Treatment for Pregnant Women Who Abuse Drugs

This project targets African American adolescents with obesity and their parents. SMARTs are used to develop an adaptive intervention that increases skills in changing dietary, exercise, and sedentary behaviors.

  • PI: Sylvie Naar-King
  • Location: Wayne State University
  • Funding: NHLBI Project U01HL097889

Adaptive Treatment Strategies for Children and Adolescents With Obsessive-Compulsive Disorder (OCD)

For youth with OCD, the most common treatments are cognitive-behavioral therapy (CBT), pharmacological treatment, or both. Up to 30% of patients may not benefit from their initial treatments. Researchers will employ a SMART to determine the optimal treatment sequence for participants dependent on whether or not they respond to their initial treatment.

  • PI: Roseli Shavitt
  • Location: University of Sao Paulo

Pilot SMART for Adolescent Depression

Adolescents suffering from depression begin treatment with interpersonal psychotherapy. This pilot project employs a SMART design to help establish treatment rules regarding when and in what way to intensify treatment.

  • PI: Meredith L. Gunlicks-Stoessel
  • Location: University of Minnesota, Twin Cities
  • Funding: NIMH Project K23MH090216

Adaptive Treatment for Persistent Insomnia

This project aims to develop an adaptive intervention for persistent insomnia. Researchers are using a SMART design to determine the best sequencing of cognitive behavioral therapy and medication for persistent insomnia.

  • PI: Charles Morin
  • Location: Laval University
  • Funding: NIMH Project R01MH091053

Adaptive Treatment for Bipolar Disorder

Patients suffering from bipolar disorder are assigned to one of two mood stabilizers. A SMART design is used to determine the appropriate treatment for patients who develop depression.

  • PIs: Charles Lee Bowden, Joseph Calabres
  • Locations: University of Texas Health Science Center at San Antonio, 2nd site: Case Western Reserve University Medical Center
  • Funding: NIMH Project P30MH086045

Pilot SMART for Personalizing Treatment for Child Depression

This pilot project uses a SMART design to develop an adaptive intervention for children with depression. Dr. Eckshtain aims to develop decision rules regarding the use of cognitive behavioral treatment, caregiver–child treatment, or both. The goal is to develop an adaptive treatment protocol for depressed children.

  • PI: Dikla Eckshtain
  • Location: Judge Baker Children’s Center at Harvard Medical School
  • Funding: NIMH Project K23MH093491

Characterizing Cognition in Nonverbal Individuals With Autism

In order to develop communication skills among school-aged children who are nonverbal, this project employs a SMART design to test a novel intervention. The intervention includes components that focus on spoken language and the use of a speech-generating device (e.g., iPad). The SMART design provides the data needed to define response and nonresponse to the intervention and identify the best treatment sequence.

  • PI: Connie Kasari
  • Location: Center for Autism Research and Treatment, University of California, Los Angeles
  • Funding: Funded by Autism Speaks

Adaptive Interventions for Minimally Verbal Children With Autism Spectrum Disorder in the Community

This study will compare two types of intensive, daily instruction for children with autism spectrum disorder (ASD) who use only minimal verbal communication. Earlier research has shown that even after early language-skills training, about one-third of school-aged children with ASD remain minimally verbal. Researchers plan to enroll 200 children in four cities: Los Angeles, Nashville, New York City, and Rochester, N.Y.

  • PI: Connie Kasari
  • Location: Center for Autism Research and Treatment, University of California, Los Angeles
  • Funding: NICHD Project R01HD073975

Adaptive Intervention Strategies in Conduct Problem Prevention: Pilot Study

Adaptive Intervention Strategies in Conduct Problem Prevention: Pilot Study

This study compares two types of interventions for youth (ages 10-15) with conduct disorders. Participants received either a teen-focused or parent-focused intervention. The appropriate intensity of the interventions was also studied.

  • PI: Gerald August
  • Location: University of Minnesota
  • Funding: NIMH Project R34MH097832

SMART Design for Attendance-Based Prize Contingency Management (CM) for Cocaine Abuse

Contingency management (CM) is a treatment used in Cocaine Misuse where patients are rewarded for following treatment guidelines. In this study, researchers are comparing CM to treatment without incentives using a SMART design. They are also testing the timing and the length of the CM.

  • PI: Nancy Petry
  • Location: University of Connecticut Health Center
  • Funding: NIDA Project R01AA021446

Adaptive Treatment for Smoking Among People With HIV

Adaptive Treatment for Smoking Among People With HIV

Between 50% and 70% of people living with HIV are nicotine dependent. This SMART examines how and when to apply contingency management and standard treatment to promote smoking cessation in this population.

  • PI: David Ledgerwood
  • Location: Wayne State
  • Funding: NIMH Project R01DA034537

Pilot SMART for Treating ADHD in Families

Pilot SMART for Treating ADHD in Families

This project aims to develop an adaptive intervention for families where the mother has ADHD and the child is at genetic and environmental risk for ADHD. Researchers are using SMART to determine how to use behavioral training or medication for mothers separately, in sequence, or in combination, to improve the quality of parenting and prevent the progression of ADHD in children.

  • PIs: Mark Stein and Andrea Chronis-Tuscano
  • Location: Seattle Children’s Hospital
  • Funding: NIMH Project R34MH99208

Improving Mental Health Outcomes: Building an Adaptive Implementation Strategy

Improving Mental Health Outcomes: Building an Adaptive Implementation Strategy

This SMART is cluster-randomized. Randomization occurs at the clinic level. The aim of the study is to develop an adaptive quality improvement strategy designed to enhance the implementation of an evidence-based mental health intervention. Outcomes are measured at the patient level.

  • PI: Amy Kilbourn
  • Location: University of Michigan
  • Funding: NIMH Project R01MH099898

Adaptive Intervention for Suicide Prevention Among College Students

Adaptive Intervention for Suicide Prevention Among College Students

Researchers in this study are developing an adaptive treatment to address suicidality in college students seeking services at college counseling centers. They are developing the first empirically validated approach to sequence treatments for students seeking services.

  • PI: Jacqueline Pistorello
  • Location: University of Nevada, Reno
  • Funding: NIMH Project R34MH104714

Pilot SMART for Elementary Students With Autism Spectrum Disorder

This project will develop an adaptive intervention to improve ​social connectedness​, academic engagement, and other skills among school-aged children with autism spectrum disorder​. Treatment for each participant includes some combination of a playground-based intervention, a classroom-based intervention, a peer-mediated intervention, and a parent-assisted intervention.​ This pilot project will address feasibility and acceptability concerns and will provide preliminary data for a full-scale SMART.

  • PI: Connie Kasari
  • Location: Center for Autism Research and Treatment, University of California, Los Angeles
  • Funding: Funded by Institute of Educational Sciences

Portions of this website and the related scientific research were funded by National Institute on Drug Abuse (NIDA) awards P50 DA039838 and P50 DA010075 to The Methodology Center at Penn State, Institute for Educational Sciences award R324B180003 and NIDA award R01 DA039901 to the University of Michigan.